chemoresistance

Explaining why some cancers do not respond to treatment with chemotherapy drug: 5-Fluorouracil (5-FU)

The NCI defines recurrence as cancer that returns after a patient has had no signs of out-of-control cell growth for at least a year

Working with mouse models of colon and breast cancer, researchers demonstrated that when combined with chemotherapy, the nanoparticle reduced tumor growth substantially more than chemotherapy alone

Chemoresistance or the specific resistance acquired by cells to the action of certain chemicals commonly hinders the treatment of cancer. Existing ways to address this issue revolve around using competitive inhibitors, but have limited success. Now, a research team led by Assistant Professor Edward Chow of the Cancer Science Institute of Singapore (CSI) at NUS has found that binding multiple molecules of a common leukaemia drug with nanodiamonds can neutralise chemoresistance.