The Waters Xevo CDMS

Waters Xevo CDMS Empowers Lab Managers to Tackle Therapeutic Complexity

Waters Xevo CDMS empowers lab managers with fast, efficient mass spectrometry for large biomolecules, streamlining workflows and improving decision-making.

Written byCraig Bradley
| 1 min read
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Waters Corporation has released the Xevo Charge Detection Mass Spectrometer (CDMS), a significant innovation aimed at overcoming the analytical challenges of today’s complex biomolecular therapies. This tool allows lab managers and teams to confidently analyze mega-mass molecules with greater speed and efficiency, supporting critical decisions in R&D and process development.

With next-gen therapies like viral vectors and mRNA vaccines requiring more nuanced analysis, the Xevo CDMS offers a robust solution that:

  • Reduces sample volume requirements by up to 100-fold.
  • Achieves precise mass analysis at concentrations as low as 10^10 vp/mL.
  • Generates results in under ten minutes.
  • Works seamlessly across discovery, development, and manufacturing workflows.

"We are proud to introduce the first-of-its-kind Xevo Charge Detection Mass Spectrometer, enabling the precise analysis of previously unmeasurable molecules," said Udit Batra, Ph.D., President and CEO of Waters Corporation.

Enhancing Lab Operations

The Xevo CDMS is powered by GxP-ready waters_connect™ Software and features the Electrostatic Linear Ion Trap (ELIT) for direct ion measurement. This eliminates the need for complex deconvolution or digestion workflows, streamlining lab operations.

Timothy Fenn, Ph.D., VP of Analytical Development and QC at Lexeo Therapeutics, added, "With CDMS, we're asking questions we didn't know we could ask. It's a game-changer for our analytical workflows."

Why It Matters for Lab Managers:

  • Accelerates time-to-data for critical therapies.
  • Increases compliance readiness and analytical confidence.
  • Reduces operational bottlenecks in high-throughput settings.

Available for order now, the Xevo CDMS supports labs in staying ahead of therapeutic innovation while optimizing day-to-day performance.

About the Author

  • Person with beard in sweater against blank background.

    Craig Bradley BSc (Hons), MSc, has a strong academic background in human biology, cardiovascular sciences, and biomedical engineering. Since 2025, he has been working with LabX Media Group as a SEO Editor. Craig can be reached at cbradley@labx.com.

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