Reliable, Quantitative Tools for AAV Vector Quality Control
Amsbio has introduced a new range of Adeno-Associated Virus (AAV) reference standards, meticulously characterized to help researchers enhance the quality, reliability, and reproducibility of AAV production processes. These standards are especially valuable in gene therapy applications, where accurate measurement and consistency are critical.
AAV vectors are widely used in gene therapy due to their safety and ability to deliver genetic material without integrating viral genes. However, one persistent challenge in AAV production is the prevalence of empty capsids—viral particles lacking therapeutic payloads. These can impact efficacy and safety if not accurately accounted for.
Full and Empty Capsid Standards for Key Assay Calibration
To address this, Amsbio now offers:
- Full AAV Reference Standards: Used to calibrate qPCR and ELISA assays, validate test methods, and establish benchmarks for critical quality attributes.
- Empty AAV Reference Standards: Essential for assessing full-to-empty capsid ratios and quantifying product purity using analytical methods such as qPCR, HPLC, and ELISA.
Each standard undergoes extensive characterization using ddPCR, ELISA, silver staining, mass photometry, and full safety testing, including bioburden, mycoplasma, and endotoxin checks.
Consistency Across Labs and Regulatory Confidence
The highly characterised and well-defined reference standards available from Amsbio are essential for quantitative AAV production. Their comprehensive characterization is vital for standardizing measurements, ensuring consistency across experiments, and providing reliable data for gene therapy applications and other research involving AAV vectors.
Importantly, all reported quantification data is traceable to ATCC Reference Standard Material, ensuring confidence and compatibility with regulatory and quality control frameworks.
For more information, visit Amsbio AAV Reference Standards.
