The role of TIMS-MS in ensuring high purity in biopharmaceuticals

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Theoretical vs measured abundance (mean average) of simulated HCPs in % of 4 ng UPS2 in 200 ng NISTmAb

Number of unique peptides identified for HCPs using (A) native digest and UPLC-MS/MS (yellow) and TIMS QTOF-MS/MS (blue); and (B) HILIC fractionation and UPLC-MS/MS (orange) and TIMS QTOF-MS/MS (blue).

Number of unique peptides identified for HCPs using (A) native digest and UPLC-MS/MS (yellow) and TIMS QTOF-MS/MS (blue); and (B) HILIC fractionation and UPLC-MS/MS (orange) and TIMS QTOF-MS/MS (blue)

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The Role of TIMS-MS in Ensuring High Purity in Biopharmaceuticals

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