Health Science

Researchers at the University of Delaware have developed a “smart” hydrogel that can deliver medicine on demand, in response to mechanical force.

With the flu and cold season in full swing, kinesiology professor Karin Richards, at University of the Sciences in Philadelphia, said many people tend to ignore their symptoms to keep on track with their fitness resolutions for the New Year. In fact, Richards said working out while under the weather can actually do more harm than good for individuals looking to shed a few pounds and adopt healthier lifestyles.

Vaccines combat diseases and protect populations from outbreaks, but the life-saving technology leaves room for improvement. Vaccines usually are made en masse in centralized locations far removed from where they will be used. They are expensive to ship and keep refrigerated and they tend to have short shelf lives.

By the time they’re two, most children have had respiratory syncytial virus (RSV) and suffered symptoms no worse than a bad cold. But for some children, especially premature babies and those with underlying health conditions, RSV can lead to pneumonia and bronchitis – which can require hospitalization and have long-term consequences.

The team of Johannes Zuber at the Institute of Molecular Pathology (IMP) in Vienna, Austria, managed to overcome remaining key limitations of RNA interference (RNAi) - a unique method to specifically shut off genes. By using an optimized design, the scientists were able to inhibit genes with greatly enhanced efficiency and accuracy. The new method facilitates the search for drug targets and improves the interpretation of experimental results. The IMP will make this „RNAi toolkit“ available to researchers. Results of the study are published in the current issue of Cell Reports.















