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Top 4 Signs that You Should Service or Replace Your Freeze Dryer

This category also includes questions you should ask when buying a freeze dryer

Lab Manager

Top 4 Signs That You Should Service or Replace Your Freeze Dryer

Your application has changed. The freeze dryer was intended for aqueous samples, now solvents or acids are used. A temperature differential is required for proper freeze drying; an upgrade to a cascade model is recommended.
The freeze dryer was inherited from another lab. A used freeze dryer can cause problems. Rubber parts dry out and crack, decontamination may not have been done properly. A used pump can have corrosion that can’t be seen until it’s too late.
Sharing a community freeze dryer. Personal freeze dryers used by a single researcher are more popular than ever. No more guessing if an oil change was done, or if a harmful sample is being processed.
The unit no longer pulls a good vacuum. Gaskets, hoses and all rubber components break down over time causing poor vacuum and refrigeration leaks.

Top 5 Questions You Should Ask When Buying A Freeze Dryer

What solvents are you using? A temperature differential between the sample’s eutectic temperature and collector temperature of 15 – 20 degrees is required. If solvents such as acetonitrile are used, a cascade freeze dryer is required.
How much sample in liters will you run? When choosing a freeze dryer, vendors recommend loading 1/2 of the listed capacity. For example, a 6L freeze dryer will hold 3L during the run.
Do you want to freeze dry in flasks, tubes, or bulk? Many drying accessories are available. On a manifold or drying chamber, flasks can be placed on each port. Test tubes and serum vials can be placed inside of the flasks for multiple samples per container. If samples are bulk, a tray dryer would be a good choice.
Do you need to stopper under vacuum? Accessories can allow you to stopper under vacuum or nitrogen without using compressed gas.
Is this a shared freeze dryer? A hybrid pump is recommended to prevent damage to the pump.

The use of freeze dryers extends from applications in academic labs to zoos. Moreover, this technology contributes to basic research and manufacturing. For example, scientists at a zoo might use a freeze dryer to increase the concentration of a tranquilizer so that it works for larger animals such as bears or even elephants.

Recently Released Freeze Dryers

-105° FreeZone® Freeze Dry System

  • Includes ice holding capacity for light to moderate loads and have dual refrigeration systems for samples with very low eutectic points
  • Provides a compact benchtop design and include a 12-port drying chamber
  • -105°C 4.5 liter systems remove over 4 liters of water in 24 hours


Revo® and Magnum® Series

  • Feature an all new Clean In Place (CIP) option
  • Gives users the option to perform a basic rinse to remove residue material or a full, multi-stage cleaning cycle using detergent, rinses and even hot air drying phases
  • CIP systems are capable of 95 to 98% coverage of all internal surfaces



  • Features trap cooling temperature of up to -45°C
  • Ice holding capacity is 1L/time
  • Safety features include: automatic operation for vacuum pump, monitoring for vacuum degree and trap temperature, stop watch, selecting the setting for power recovery
  • Includes sheet key type, digital display


Advantage Plus

  • Can freeze dry bulk product or be configured for applications in stoppered vials
  • Side-mounted manifold valves provide the additional flexibility to freeze dry product in flasks
  • hree refrigeration choices (-53°C, -70°C, or -85°C) are available for the large 6-litre capacity condenser
  • Comes with a two-year refrigeration warranty and includes CE marking


Freeze Dryer Manufacturers



Hanil (NA:



SP Scientific