Basis for novel insights into tissue regeneration

These molecular machines are often as elaborate as man-made devices, but exactly how they work is much harder to understand because of their extremely small size

The team of Johannes Zuber at the Institute of Molecular Pathology (IMP) in Vienna, Austria, managed to overcome remaining key limitations of RNA interference (RNAi) - a unique method to specifically shut off genes. By using an optimized design, the scientists were able to inhibit genes with greatly enhanced efficiency and accuracy. The new method facilitates the search for drug targets and improves the interpretation of experimental results. The IMP will make this „RNAi toolkit“ available to researchers. Results of the study are published in the current issue of Cell Reports.