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Raman Spectrophotometers

Learn recent trends in Raman spectrophometers as well as some of the main questions you should ask before buying one.

by Other Author

Recent Trends in Raman Spectrophotometers

• Once massive benchtop instruments that required a Ph.D. to operate, portable Raman spectrophotometers are now a booming business, with the latest instruments being more approachable for non-experts, smaller, and lower in cost.

• Demand for portable Raman and other portable instruments continues to grow as applications expand beyond jewelry, pharmaceutical, military, and mining and exploration applications into industries such as food inspection, especially with more and more of our produce being imported to the U.S.

• Raman is effective for noncontact, nondestructive chemical analysis. Its attraction has been its applicability to many sample types with no preparation required. However, according to one expert, small-molecule drug development and manufacturers have been slow to adopt Raman, and biologicals have been even slower. This is likely due to a lack of trained spectroscopists in the biotech world and a lack of such training among process engineers and biologists.

Top 5 Questions You Should Ask When Buying a Raman Spectrophotometer

1. Can this system measure my sample of interest in my measurement environment? Depending on the sample you’re using (surface, bulk, process, etc.) and your environment (laboratory, field, loading dock, etc.) it will be important to know if you need a portable, benchtop, fiber optic based or micro-Raman system.

2. How easy is it to switch from one type of sample to another when using your system? If you plan on measuring a diverse range of samples, fiber optic based systems afford you a high degree of sampling utility, whereas if you’re looking to measure one specific type of sample under a constant environment over and over again, you may want to choose a more dedicated setup.

3. What level of expertise is needed to operate this system? A highly technical user will want a lot of software flexibility, whereas a novice will want something very easy and intuitive.

4. What excitation wavelengths are available for your system? Depending on whether you are using organic vs. inorganic materials, you will want a specific wavelength to get the best results and you should research which wavelength will work best for your specific application.

5. Does your system contain a back-thinned or front illuminated detector? Depending on the concentration and the degree to which the sample is Raman active, you will need to make sure to select the detector with the proper sensitivity.

Recently Released Raman Spectrophotometers

• Support a broad range of applications in multiple industries
• Easy to use and operates single-handedly
• Allows rapid development of standardized and validated methods to facilitate 100% inspection for purity and quality
• Includes CleanLaze® technology for exceptional laser stabilization and narrow linewidth

B&W Tek, Inc.

TruScan RM and microPHAZIR RX
• Thermo’s family of complementary handheld material identity analyzers utilize both NIR and Raman spectroscopy
• Enable rapid material verification at the point of need
• Provide a portable solution to achieve quality standards throughout the manufacturing process
• Greater than 500 GMP facility installations worldwide

Thermo Fisher Scientific

Innova-IRIS AFM System
• Suitable platform for challenging Tip-Enhanced Raman Spectroscopy (TERS) research
• Features hardware integration specifically designed to accelerate a TERS setup
• Includes IRIS software module that offers automated mapping
• Compatible with leading Raman systems and implements the optimized off-axis Raman geometry necessary for maximum sensitivity
• Accelerates setup and data acquisition


Raman Systems
• Fully integrated for handheld, laboratory and educational applications
• Most systems include a high-sensitivity spectrometer , a 532 nm or 785 nm laser, operating software and accessories
• Modular options available for users who configure their own Raman systems
• Raman accessories such as lasers, microscope kits, probes and even safety glasses are also offered

Ocean Optics

Apollo™ Raman Microspectrometer
• Fits to most of the major brands of optical microscopes
• Allows users to collect Raman spectra from microscopic samples or microscopic sampling areas of larger samples
• With a single microscope, users can image samples and then measure the vibrational spectra of microscopic sample areas without further sample preparation or moving to another instrument


Raman Spectrophotometer Manufacturers

B&W Tek
Bruker Optics
Enwave Optronics
Horiba Scientific
Malvern Instruments
Ocean Optics
Thermo Fisher Scientific