Microfluidic cell-squeezing device opens new possibilities for cell-based vaccines.

Vegetable-based muscles that can expand and contract while bending described in the journal "Applied Physics Letters."

In certain types of cancer, nerves and cancer cells enter an often lethal and intricate waltz where cancer cells and nerves move toward one another and eventually engage in such a way that the cancer cells enter the nerves.

University of Texas at El Paso researchers' work challenges the theory that feeder cells provide nutrients to growing stem cells.

Lysosomes are the garbage disposals of animal cells. As the resources are limited in cells, organic materials are broken down and recycled a lot — and that’s what lysosomes do. Detecting problems with lysosomes is the focus of a new set of fluorescent probes developed by researchers at Michigan Technological University. The Royal Society of Chemistry published their work in January.

Scientists at Albert Einstein College of Medicine of Yeshiva University and their international collaborators have developed a novel fluorescence microscopy technique that for the first time shows where and when proteins are produced. The technique allows researchers to directly observe individual messenger RNA molecules (mRNAs) as they are translated into proteins in living cells. The technique, carried out in living human cells and fruit flies, should help reveal how irregularities in protein synthesis contribute to developmental abnormalities and human disease processes including those involved in Alzheimer’s disease and other memory-related disorders. The research will be published the March 20 edition of Science. 

Facing a challenge akin to solving a 1,000-piece jigsaw puzzle while blindfolded—and without touching the pieces—many structural biochemists thought it would be impossible to determine the atomic structure of a massive cellular machine called the nuclear pore complex (NPC), which is vital for cell survival.

A team led by structural biologists at The Scripps Research Institute (TSRI) has taken a big step toward understanding the intricate molecular mechanism of a metabolic enzyme produced in most forms of life on Earth.

New details revealed in the coordinated regulation of large stretches of DNA.

From new insights into the building blocks of matter to advances in understanding batteries, superconductors, and a protein that could help fight cancer, 2014 was a year of stunning successes for the U.S. Department of Energy's Brookhaven National Laboratory. Oh, and did we mention the opening of a brand new facility that will push the limits of discovery across the scientific spectrum? For details on these and the rest of our Top-10 breakthroughs, check out the items below. You can follow Brookhaven Lab on Facebook, Twitter, and Tumblr to learn about the discoveries of 2015 as they happen.