KU Cancer Center researchers are developing approaches to manipulate the DNA damage response to treat and prevent disease

Targeting pathway could increase potency of some current drugs

Achievement using cryo-electron microscopy to aid gene research and drug development

SDSC’s ‘Gordon’ helps describe complex process that’s fundamental to cancer initiation

This enzyme—known as Flap endonuclease 1, or FEN1—is often highly overexpressed or faulty in cancer and other types of diseases

Researchers now know how key proteins get where they need to be to facilitate the process

Time-lapse imaging helps provide new insights into process