Lab Manager | Run Your Lab Like a Business

Product Application News

Using the NanoDrop 3300 Fluorospectrometer for Cancer Research Applications

Epigenetic modifications are defined as heritable information other than nucleotide sequences (1) that have the ability to control how and when transcription takes place. DNA methylation and secondary DNA structures such as DNA Gquadruplexes are among the epigenetic modifications currently under study because of their common associations with cancer (1,2).

Automated Detection of Drug-Induced Lysosomal Cytotoxicity - Automation of the Lyso-ID Red Assay Using the EL406 Combination Washer Dispenser

Almost all drug compounds will elicit deleterious effects on cells at some concentration. Lysosome perturbation as a result of ion trapping of amine containing compounds has been demonstrated to cause the formation of autophagosomes and autophagic cytopathology. Here we describe the use of the EL406 Combination Washer Dispenser to automatically aspirate media, wash cells and dispense reagents for the Lyso-ID Red Detection kit, part of the CELLestial Live Cell Analysis platform from Enzo Life Sciences.

Determination of Heavy Metals in Wine Using Simultaneous ICP-OES with Mini Torch

Wine is one of the oldest cultural products in human history. Vines have been cultivated for over 8000 years. The oldest known archaeological evidence of winemaking is an 8000-year old wineand fruit press found near Damascus. Awareness of the medicinal effects of wine also date back to this time.

Understanding Metabonomics Mixtures with PCA

In toxicology studies, alterations to the intrinsic in vivo biochemical profile of an animal can be monitored via NMR spectroscopic analysis of urine. Chemometric processing of the NMR data can enhance understanding of the toxic effects; in particular, examination of the principal component analysis (PCA) scores provides insight into these data in a time-efficient manner.

Determination of a Compound's Oxidative Stability

The advent of high throughput techniques have had a profound effect on pharmaceutical companies and the drug discovery process worldwide. The numbers and types of compounds available for elucidation have increased by orders of magnitude.