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Waters and Genovis Collaborate to Develop Efficient Workflows for Biopharmaceutical Characterization

Firms working to co-develop automated biotherapeutic characterization workflows, combining Waters LC-MS instrumentation and Genovis SmartEnzymes

by Waters Corporation,

Genovis’ business concept is to apply its knowledge and customer driven innovation to design and provide tools for the development of the drugs of the future. Today Genovis sells several...

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  • Collaboration intended to bring speed and simplicity to bio-characterization workflows 
  • Automated workflows to cut the time and effort required to monitor critical quality attributes of biotherapeutics in regulated laboratories 
  • Waters and Genovis share goal of advancing the science behind the analysis of glycoproteins and protein therapeutics 

MILFORD, MA & LUND, SWEDEN — (BUSINESS WIRE) — Waters Corporation (NYSE:WAT) and Genovis AB (Nasdaq First North Growth Market) are formally collaborating to develop and market complete routine biopharmaceutical characterization workflows based on the Waters™ BioAccord™ LC-MS System, Andrew+ pipetting robot, and Genovis SmartEnzymes™. The goal of the collaboration is to develop automated workflows for the rapid and consistent characterization of critical quality attributes (CQAs) of monoclonal antibodies (mAbs) and other protein-based drugs in bioprocess development, formulation, stability testing, and quality control (QC).

“Biologics analysis is an area that is ripe for improvement. What takes analytical scientists several days to do, should take hours or minutes instead,” said Jeff Mazzeo, vice president, Global Marketing and Scientific Operations, Waters Corporation. “Today, up-front sample preparation is a major bottleneck to productivity, largely due to the number of manual steps involved and the outmoded technology by which samples are readied for analysis. By combining Genovis’ SmartEnzymes with automation, liquid chromatography/time-of-flight mass spectrometry, and application-specific software workflows from Waters, we intend to move biotherapeutic analysis forward in ways never thought possible.” 

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“The BioAccord LC-MS system and the Andrew+ pipetting robot align perfectly with our strategies and vision at Genovis to bring simplified, robust and automated enzyme-driven workflows to the biopharma industry,” said Fredrik Olsson, CEO, Genovis AB. “The enzymatic workflows that we will develop in collaboration with Waters will help our customers in their efforts to bring safe and novel therapeutics to patients, faster.” 

The workflows in development are based on the pairing of the Waters BioAccord LC-MS System, Andrew+ pipetting robot and Genovis SmartEnzymes and will focus on addressing the application needs of GxP laboratories in the following areas: 

  • Product variant analysis [e.g. glycosylation, oxidation] 
  • Bioprocess stability monitoring 
  • Biosimilar glycosylation analysis 

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