Cancer Research

Even the most careful chosen meal can contain surprises. To defend against infectious microbes, viruses or other potential hazards that find their way to the intestines, a dedicated contingent of immune cells keeps watch within the thin layer of tissue that divides the contents of the gut from the body itself.

Researchers with The Cancer Genome Atlas (TCGA) Research Network have completed the largest, most diverse tumor genetic analysis ever conducted, revealing a new approach to classifying cancers. The work, led by researchers at the UNC Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill and other TCGA sites, not only revamps traditional ideas of how cancers are diagnosed and treated, but could also have a profound impact on the future landscape of drug development.

A computer model study reveals – for the first time – details of an energy-creating process vital and unique to cancer cells. The research holds promise for new interventions and for personalizing cancer treatments based on individual needs.

Researchers at Karolinska Institutet in Sweden have headed a study that has provided new knowledge about the EphA2 receptor, which is significant in several forms of cancer. This is important knowledge in itself – but just as important is how this study, which is published in the highly respected journal Nature Methods today, was conducted. The researchers used the method of DNA origami, in which a DNA molecule is shaped into a nanostructure, and used these structures to test theories about cell signalling.













