epigenetics

A family of proteins known as histones provides support and structure to DNA, but for years, scientists have been puzzling over occasional outliers among these histones, which appear to exist for specific, but often mysterious reasons. Now, researchers have uncovered a new purpose for one such histone variant: preventing genetic mutations by keeping certain so-called “jumping genes” in place.


Stem cells in early embryos have unlimited potential; they can become any type of cell, and researchers hope to one day harness this rejuvenating power to heal disease and injury. To do so, they must, among other things, figure out how to reliably arrest stem cells in a Peter Pan-like state of indefinite youth and potential. It’s clear the right environment can help accomplish this, acting as a sort of Neverland for stem cells. Only now are scientists beginning to understand how.

Some people take stress in stride; others are done in by it. New research at Rockefeller University has identified the molecular mechanisms of this so-called stress gap in mice with very similar genetic backgrounds — a finding that could lead researchers to better understand the development of psychiatric disorders such as anxiety and depression.










