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Liquid chromatography coupled with mass spectrometry(LC/MS) is one of the most powerful analytical tools for organic compound analysis.

Goal: Develop a robust LC/MS method for the analysis of illicit drug salt forms.

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Goal:Optimize a UHPLC/MS method with respect to stationary phase, mobile phase, and detector settings to achieve picogram level quantitation of 14 drugs and metabolites employing a 12 minutes separation.

Positively identify trace amounts of cannabinoids in a complex food matrix quickly, with minimal sample preparation and no chemical derivatization. 

Simvastatin, (together with mevastatin and lovastatin in Figure 1), a hypolipidemic drug belonging to the “statin” family, is commonly used to control elevated cholesterol levels and to prevent cardiovascular diseases.

Vitamin D status has been associated with a variety of disease states including cancer, cardiovascular disease, diabetes, multiple sclerosis, osteoporosis, rheumatoid arthritis, and chronic pain.

LC/MS provides an excellent alternative to conventional LC with UV, PDA or Fluorescence detection or GC/MS to measure polar pesticides in food matrices and in the environment. Many of these pesticides are not very volatile and have to be derivatized