The team of Johannes Zuber at the Institute of Molecular Pathology (IMP) in Vienna, Austria, managed to overcome remaining key limitations of RNA interference (RNAi) - a unique method to specifically shut off genes. By using an optimized design, the scientists were able to inhibit genes with greatly enhanced efficiency and accuracy. The new method facilitates the search for drug targets and improves the interpretation of experimental results. The IMP will make this „RNAi toolkit“ available to researchers. Results of the study are published in the current issue of Cell Reports.