New research from the Journal of Medicinal Chemistrymay help millions stick to a common resolution: quitting smoking. Researchers at the Scripps Institute in La Jolla, California, are working on a nicotine vaccine that could put an end to the addiction. Kim Janda, Ph.D.'s approach is to get the body's immune system to treat nicotine like a foreign invader. But getting the body to respond in the right way is a big challenge. The video, the first from the newly launched ACS Headline Science series, is available at http://youtu.be/jfbL8quK3a0.