The ever-increasing sophistication of today’s laboratory technologies means that scientific researchers must be constantly finding new ways to improve the quality, efficiency, and pace of their research to ensure success.

Early in the evolution of chromatography- mass spectrometry, one could consider the two components as separate boxes requiring a good deal of engineering to link them together.

Liquid chromatography coupled with mass spectrometry(LC/MS) is one of the most powerful analytical tools for organic compound analysis.

Goal: Develop a robust LC/MS method for the analysis of illicit drug salt forms.

Goal:Optimize a UHPLC/MS method with respect to stationary phase, mobile phase, and detector settings to achieve picogram level quantitation of 14 drugs and metabolites employing a 12 minutes separation.