HILIC is an increasingly popular alternative to reversed-phase LC for challenging polar analytes

As leading instrument and column makers continue to innovate, legacy methods, particularly in highly regulated pharmaceutical and environmental industries, continue to nudge the state of the art toward greater robustness and familiarity and away from the cutting edge.

Kinetex® Meets researchers’ need to improve results and increase productivity without large capital expenditures Delivers significant improvements in speed and separation efficiency over traditional 3- and 5-micron

Accucore™ 150-C18 & 150-C4 Designed to improve protein and peptide assay robustness Enhance peak capacity and run times at moderate operating pressures 150-C18 has been further optimized for biomolecules and

In HPLC columns, reverse-phase and normal-phase chromatography separation methods are based on polarity. Reverse phase columns separate analytes based on their hydrophobicity, with the more hydrophobic compounds being retained longer on the column.

Column technology has been a rich area for HPLC R&D. As reasonably expensive consumables, columns are a significant factor in LC operating costs and performance— in other words, key value drivers.