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From millimeters to sub-nanometers, accurately measuring particle size is essential in determining the usefulness and performance characteristics of a material.

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Article Thumbnail - Interpretation of Particle Size Reported by Different Analytical Techniques

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Interpretation of Particle Size Reported by Different Analytical Techniques

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Nanoparticle characterization allows researchers to determine critical attributes such as size, shape, surface charge, and distribution, all of which influence a nanoparticle’s functionality, properties, stability, and interactions with biological systems or other materials. This is all the more important as nanoparticles find prominence in applications such as drug delivery systems and advanced materials fabrication.&nbsp;<figure data-id="froala-uploading-image-1726075588758" class="fr-image-container fr-quarter fr-right"><picture><img class="fr-fil fr-dib" data-id="52111" src="https://cdn.labmanager.com/assets/image/52111/malvern-cover-2-l.jpg" alt="Shedding Light on Nanoparticle Characterization" title="Shedding Light on Nanoparticle Characterization" loading="lazy"></picture><figcaption class="fr-figcaption"> </figcaption></figure>Among the various techniques available for characterizing nanoparticles, Dynamic Light Scattering (DLS) allows researchers to quickly and accurately measure the hydrodynamic sizes of particles in suspension. A non-invasive technique, DLS analyzes the fluctuations in light scattering due to the Brownian motion of particles. The translational diffusion coefficient obtained from these fluctuations is used to calculate the hydrodynamic diameter of the particles. Offering rapid and accurate measurements, including high sensitivity to small particles, the ability to analyze a wide range of sizes, and minimal sample preparation, DLS is an indispensable tool for researchers and manufacturers to obtain reliable, real-time insights on nanoparticle dispersions.Malvern Panalytical’s Zetasizer Advance Series offers researchers advanced features for method development in DLS specifically to enhance the accuracy, efficiency, and flexibility of nanoparticle characterization workflows. Equipped with innovative tools including adaptive correlation, multi-angle dynamic light scattering (MADLS), and depolarized dynamic light scattering (DDLS). Reinforced by robust software that simplifies method development, the Zetasizer Advance Series sets the stage for users to optimize parameters for different samples and improve the repeatability and reliability of their analyses.Read this resource to learn more about:<ul><li>Key factors for DLS method development including instrument verification, cell selection, sample preparation, measurement setup, and analysis techniques to obtain reliable particle size measurements.</li><li>Enabling exploration of a greater size range of nanoparticles using DLS without compromising the integrity of the sample dispersant.</li><li>Characterizing nanoparticles at the upper size range for DLS, and how to use the Zetasizer’s Low Volume Disposable Sizing Cell Case studies to offset errors introduced by sedimentation, thermal currents, and number fluctuations, that may lead to inaccurate size analysis.</li><li>Using MADLS on the Zetasizer Ultra for rapid QC of gold nanoparticles, identification of off-spec samples, reducing reliance on TEM, and saving time and costs.</li></ul>Download this resource guide to reinforce and enhance nanoparticle characterization workflow using the DLS technique.&nbsp;

Shedding Light on Nanoparticle Characterization 

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Shedding Light on Nanoparticle Characterization

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