Analytical Chemistry

Facing a challenge akin to solving a 1,000-piece jigsaw puzzle while blindfolded—and without touching the pieces—many structural biochemists thought it would be impossible to determine the atomic structure of a massive cellular machine called the nuclear pore complex (NPC), which is vital for cell survival.

With its new 875 Karl Fischer Gas Analyzer, Metrohm combines decades of experience in moisture analysis and sample handling. The KF Gas Analyzer is designed to handle nearly any gas sample – compressed, liquefied or native. It is fully equipped to measure the absolute moisture content of LPG, petrochemical intermediates, natural gas or other compressed or liquefied gases.

Greg Martin is president of Complectors Consulting (www.complectors.com), based in Pottstown, PA, which provides consulting and training in the area of pharmaceutical analytical chemistry. Mr. Martin has over 25 years of experience in the pharmaceutical industry and was director of pharmaceutical analytical chemistry (R&D) for a major PhRMA company for a number of years. In addition, he has volunteered for the U.S. Pharmacopeia for over 10 years, and currently serves as vice chair of the General Chapters—Physical Analysis Expert Committee and also serves on expert panels on Validation and Verification; Weights and Balances’ Residual Solvents; and Use of Enzymes for Dissolution Testing of Gelatin Capsules.

Malvern Instruments has released new guidance on using automated image analysis to detect and quantify agglomerates. The ability of uncontrolled agglomeration to substantially impact the performance and value of powder products makes efficient agglomerate detection vital across a number of industries.

This application note shows how the Thermo Scientific™ K-Alpha™+ XPS system, along with a dual mode monatomic and gas cluster ion source, was used to observe the effects of cleaning metal oxides with ionized argon clusters.

Rigaku's Handheld Raman Analyzer Wins IBO Award for Portable Analytical Instrument Industrial Design
Rigaku Raman Technologies, a leading pioneer of handheld and portable Raman spectrometers, is delighted to announce that its handheld Raman analyzer, Progeny™ (www.rigakuprogeny.com) has received the Bronze Award for the Portable Analytical Instrument Industrial Design category in the 2014 Instrument Business Outlook (IBO) Design Awards.

Laboratories at The Scripps Research Institute (TSRI) are investigating antibodies to fight Ebola virus, including the three antibodies recently used to treat two American health care workers infected with the Ebola virus.

The warm beauty of amber was captivating and mysterious enough to inspire myths in ancient times, and even today, some of its secrets remain locked inside the fossilized tree resin. But for the first time, scientists have now solved at least one of its puzzles that had perplexed them for decades. Their report on a key aspect of the gemstone’s architecture appears in the ACS journal Analytical Chemistry.

Thermal analysis is the broad category of at least 20 techniques that measure some fundamental property of matter as a result of adding heat. For example, dilatometry measures volume changes upon heating, thermomechanical analysis quantifies the change in dimension of a sample as a function of temperature, and thermo-optical analysis detects changes in optical properties on heating or cooling.











