INSIGHTS on Streamlining Clone Selection

by Angelo DePalma, PhD

Like great athletes and musicians, cells employed in cell-based assays or as expression systems for biopharmaceutical production are not born, but made. Cell lines that perform specifically and predictably arise from a population of cells that have undergone one or more genetic transformations (transfection) and are subsequently selected for desirable properties such as viability, protein or virus production; high culture density; or binding to drugs or antigens.

Researchers Create 'Naive' Pluripotent Human Embryonic Stem Cells

by Nicole Giese Rura-Whitehead Institute for Biomedical Research News Office

For years, researchers and patients have hoped that embryonic stem cells (ESCs)—capable of forming nearly any cell type in the body—could provide insight into numerous diseases perhaps even be used to treat them. Yet progress has been hampered by the inability to transfer research and tools from mouse ESC studies to their human counterparts, in part because human ESCs are “primed” and slightly less plastic than the mouse cells.

'Cloning' Could Make Structurally Pure Nanotubes for Nanoelectronics

by Other Author
Researchers from the University of Southern California (USC) and the National Institute of Standards and Technology (NIST) have demonstrated a technique for growing virtually pure samples of single-wall carbon nanotubes (SWCNTs) with identical structures, a process they liken to "cloning" the nanotubes.