National Institutes of Health

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded a $1.5 million grant from the National Institutes of Health (NIH) to develop drug candidates that could treat cancer and neurodegenerative disease.

A Washington University in St. Louis drug discovery program has received three grants totaling more than $5 million from the National Institutes of Health (NIH) to develop new therapeutics for respiratory diseases. The target illnesses range from the common cold to life-threatening lung disease.

The test would quickly diagnose patients in remote locations where disease spread has been rampant.

Using a new imaging technique, National Institutes of Health researchers have found that the biological machinery that builds DNA can insert molecules into the DNA strand that are damaged as a result of environmental exposures. These damaged molecules trigger cell death that produces some human diseases, according to the researchers. The work, appearing online Nov. 17 in the journal Nature, provides a possible explanation for how one type of DNA damage may lead to cancer, diabetes, hypertension, cardiovascular and lung disease, and Alzheimer’s disease.

A genetically diverse mouse model is able to predict the range of response to chemical exposures that might be observed in human populations, researchers from the National Institutes of Health have found. Like humans, each Diversity Outbred mouse is genetically unique, and the extent of genetic variability among these mice is similar to the genetic variation seen among humans.

A $10 million grant over five years from the National Institutes of Health will establish a prestigious Institutional Development Award (IDeA) Center of Biomedical Research Excellence (COBRE) in Matrix Biology at Boise State University. COBRE centers promote collaborative, interactive efforts among researchers with complementary backgrounds, skills and expertise.












