Helium is commonly used as the makeup gas for flame ionization detection in gas chromatography;
however, dramatic increases in cost and limited availability in recent years have led many chromatographers to use nitrogen in its place.

Chemical processing and analysis are fueling a resurgence of interest in highly purified specialty gases. Novel gas-phase chemical reactions reduce the number of unit operations and side products while eliminating the disposal of toxic solvents.

In-house generation promises improved safety, increased convenience and reduced gas costs.