Cartoon depiction of Treg cells in action

2025-nobel-prize-in-physiology-or-medicine-honors-discoveries-in-immune-tolerance

Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi are recognized for revealing how regulatory T cells prevent the immune system from attacking the body

2025 Nobel Prize in Physiology or Medicine Honors Discoveries in Immune Tolerance

News

3D render of red T-cells attacking blue cancer cells

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University of North Carolina Health Care

New study demonstrates using T cells against solid tumors effectively

Harnessing T Cells to Advance Solid Tumor Immunotherapy

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Scientists Discover New T Cells and Genes Related to Immune Disorders

RIKEN

These findings employed a novel genomics method made possible by a newly developed technology called ReapTEC

Genetic engineering concept. Medical science. Scientific Laboratory.

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Automated PBMC isolation and T cell wash and concentration

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Figure 1. Simplified cell therapy workflow.

Figure 2. The CTS Rotea Counterflow Centrifugation System.

Figure 3. PBMC isolation using the CTS Rotea system. (A) Viability and recovery of PBMCs and (B) relative proportions of cell types present in an unprocessed Leukopak bag and after PBMC isolation.

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Figure 6. Average recovery and viability for two T cell wash and concentrate runs with an input of 5 x 10? cells.

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Table 3. T cell wash and concentrate protocol.

Figure 4. T cell expansion. (A) Expansion of T cells isolated using the CTS Rotea system and a density gradient medium. (B) Characterization of the expanded T cells isolated using the CTS Rotea system and a density gradient medium.

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Figure 7. T cell washing and concentration. (A) T cell recovery and viability averaged over ten T cell washing and concentration runs. (B) Flow cytometry after staining of CD4 and CD8, before and after the CTS Rotea system washing and concentration protocol. (C) CTS Rotea system operating software with a chamber of T cells in a fluidized bed.

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Figure 5. Recovery and viability for T cell washing and concentration with 5 mL, 10 mL, and 20 mL output volumes.

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Thermo Fisher Scientific

Improve Your Process and Manufacturing in Cell and Gene Therapy

Whitepaper

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A Closed Cell-Processing System for Cell Therapy manufacturing

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Processing times and instrument specifications chart

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What the CTS Rotea system does at each step

Cell separation, concentration, washing, and more

Are You Looking to Improve Your Closed Cell Processing?

Image of T cells in blue, attacking a pink foreign body

A Novel Nanoplatform for Delivering Drugs into Lymphocytes

Osaka Prefecture University

A pH-sensitive drug delivery system in T cells using C-terminal dendrimers with Phenylalanine

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Eppendorf

Emerging Immunotherapy: CAR T Cells

Infographic

Spatial Transcriptomics Is Transforming Immuno-Oncology Research

Enhancing solid tumor treatment by learning the intra-tumoral address of individual cells

Insights

Get a better understanding of cellular immunity

Immudex

These DNA barcoded MHC Dextramer&reg; reagents are designed to be compatible with the BD Rhapsody&trade; system to be used for multiplexing

Immudex Launches dCODE Dextramer&reg; (RiO), a New Reagent Compatible with BD Rhapsody&trade; Single Cell Analysis System

Product News

Real-Time Detection and Modulation of Human T Cell Activation

Agilent Technologies

The XF T Cell Activation Assay delivers a convenient, consistent solution to study T cell activation and associated metabolic reprogramming

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How Lab Leaders Can Prepare for Safety Crises That Don’t Follow the Script

When the Unexpected Hits

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Eppendorf North America

epMotion&reg;: A Pipette&mdash;Only Smarter

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T-cells

2025 Nobel Prize in Physiology or Medicine Honors Discoveries in Immune Tolerance

Harnessing T Cells to Advance Solid Tumor Immunotherapy

Scientists Discover New T Cells and Genes Related to Immune Disorders

Improve Your Process and Manufacturing in Cell and Gene Therapy

Are You Looking to Improve Your Closed Cell Processing?

A Novel Nanoplatform for Delivering Drugs into Lymphocytes

Emerging Immunotherapy: CAR T Cells

Spatial Transcriptomics Is Transforming Immuno-Oncology Research

Immudex Launches dCODE Dextramer® (RiO), a New Reagent Compatible with BD Rhapsody™ Single Cell Analysis System

Real-Time Detection and Modulation of Human T Cell Activation

When the Unexpected Hits

Sponsored

epMotion®: A Pipette—Only Smarter

Matrix-Matched Centrifugation: Decisions Behind Reproducible Extracellular Vesicle Isolation

From Monitoring to Meaning: Agentic AI Strategies to Lower LabOps Operational Costs and Risks

Building a Quality-Driven Lab: A Guide to Minimizing Operational Risk