Most vaccines targeting tumor-associated antigens have had limited success so far in producing therapeutic effects against most cancers due to poor immunogenicity
Ludwig researchers discover that circular DNA, once thought to be rare in tumor cells, is actually very common and seems to play a fundamental role in tumor evolution
“This research provides insight into the mechanisms of early cancer spread and may shed light into unexplained phenomena—among them, why as many as five percent of cancer patients worldwide have cancer metastases but no original tumor"
One of the biggest challenges in cancer therapy is being able to sufficiently deliver chemotherapy drugs to tumors without exposing healthy tissues to their toxic effects
This work resulted in the award of a patent from the U.S. Patent and Trademark Office protecting the use of the compound against various forms of cancer