Overuse of antibiotics, high animal numbers, and low genetic diversity caused by intensive farming techniques increase the likelihood of pathogens becoming a major public health risk, according to new research led by UK scientists.
An international team of researchers led by the Universities of Bath and Sheffield, investigated the evolution of Campylobacter jejuni, a bacterium carried by cattle which is the leading cause of gastroenteritis in high income countries.
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Campylobacter facts:
- Causes bloody diarrhea in humans
- Transferred to humans from eating contaminated meat and poultry
- Although not as dangerous as typhoid, cholera, or E.coli, it causes serious illness in patients with underlying health issues and can cause lasting damage.
- Around one in seven people suffer from an infection at some point in their life
- Causes three times more cases than E.coli, Salmonella, and listeria combined
- Carried in the feces of chickens, pigs, cattle, and wild animals
- Campylobacter is estimated to be present in the feces of 20 percent of cattle worldwide
- The bug is very resistant to antibiotics due to their use in farming
The researchers, publishing in the prestigious journal Proceedings of the National Academy of Sciences, studied the genetic evolution of the pathogen and found that cattle-specific strains of the bacterium emerged at the same time as a dramatic rise in cattle numbers in the 20th century.
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The authors of the study suggest that changes in cattle diet, anatomy and physiology triggered gene transfer between general and cattle-specific strains with significant gene gain and loss. This helped the bacterium to cross the species barrier and infect humans, triggering a major public health problem.
Combine this with the increased movement of animals globally, intensive farming practices have provided the perfect environment in which to spread globally through trade networks.
"There are an estimated 1.5 billion cattle on Earth, each producing around 30 kg of manure each day; if roughly 20 percent of these are carrying Campylobacter, that amounts to a huge potential public health risk," said professor Sam Sheppard from the Milner Centre for Evolution at the University of Bath. "Over the past few decades, there have been several viruses and pathogenic bacteria that have switched species from wild animals to humans: HIV started in monkeys; H5N1 came from birds; now COVID-19 is suspected to have come from bats.
Our work shows that environmental change and increased contact with farm animals has caused bacterial infections to cross over to humans too. I think this is a wake-up call to be more responsible about farming methods, so we can reduce the risk of outbreaks of problematic pathogens in the future."
"Human pathogens carried in animals are an increasing threat and our findings highlight how their adaptability can allow them to switch hosts and exploit intensive farming practices," said professor Dave Kelly from the Department of Molecular Biology and Biotechnology at the University of Sheffield.
- This press release was originally published on the University of Bath website
