Goal:Optimize a UHPLC/MS method with respect to stationary phase, mobile phase, and detector settings to achieve picogram level quantitation of 14 drugs and metabolites employing a 12 minutes separation.
Simvastatin, (together with mevastatin and lovastatin in Figure 1), a hypolipidemic drug belonging to the “statin” family, is commonly used to control elevated cholesterol levels and to prevent cardiovascular diseases.
Vitamin D status has been associated with a variety of disease states including cancer, cardiovascular disease, diabetes, multiple sclerosis, osteoporosis, rheumatoid arthritis, and chronic pain.