Chromatography

Reaction screening and purification are essential steps in small molecule pharmaceutical discovery labs. Cleaner samples for subsequent synthesis can reduce reaction by-products and facilitate the critical final purification of material for pharmaceutical profiling and toxicology studies.

HPLC systems are forced to their pressure limits under fast HPLC and high resolution HPLC conditions. System back pressure issues can arise from efforts to increase efficiency and resolution such as increasing flow rates and column lengths, as well as reducing particle size.

As samples become increasingly active and more complex, labs simply cannot afford interferences caused by flow path activity in their GCs. A non-inert flow path can cause peak tailing and signal loss. Users need the most inert flow path possible to achieve the lower detection limits demanded by increasingly tough regulatory obligations.








