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Plant Compounds Give One, Two Punch to Colon Cancer, Study Shows

SLU students joined faculty mentors for early research in a cell model

by Saint Louis University
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Uthayshanker Ezekiel, PhDUthayshanker Ezekiel, PhD, transfers proteins from gel to membrane using a western blot assembly.Photo credit: Ellen HuttiST. LOUIS -- The combination of two plant compounds that have medicinal properties—curcumin and silymarin—holds promise in treating colon cancer, according to Saint Louis University research published in the June 23 issue of the Journal of Cancer.

Curcumin is the active ingredient in the spice turmeric, which is present in spicy curry dishes, and silymarin is a component of milk thistle, which has been used to treat liver disease.

The researchers and their students studied a line of colon cancer cells in a laboratory model. They found treating the cells initially with curcumin, then with silymarin was more effective in fighting cancer than treating the cells with either phytochemical alone, said Uthayashanker Ezekiel, PhD, corresponding author and associate professor of biomedical laboratory science.

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"The combination of phytochemicals inhibited colon cancer cells from multiplying and spreading. In addition, when the colon cancer cells were pre-exposed to curcumin and then treated with silymarin, the cells underwent a high amount of cell death," Ezekiel said.

"Phytochemicals may offer alternate therapeutic approaches to cancer treatments and avoid toxicity problems and side effects that chemotherapy can cause."

Ezekiel noted the research is a preliminary cell study, with more research ahead before scientists know if the compounds are an effective treatment for people who have colon cancer. He saw promise in using the phytochemicals to help prevent colon cancer, which frequently is caused by lifestyle factors such as diet.

Scientists next would need to study how the curcumin and silymarin impact the actions of molecules, such as genetic transcription and expression, that cause cells to change, Ezekiel said. Then the compounds would be studied in an animal model, then in humans.

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"Concentrations of curcumin and silymarin that are too high could be harmful to people," he said. "We still have much to learn, and for now, it's so much safer to add a little spice to your diet and get your curcumin from foods that contain turmeric, such as curry, rather than taking high doses of the compound."

A team of SLU students and another researcher from Doisy College of Health Sciences joined Ezekiel as authors of the paper. They are Amanda Montgomery, a former student in nutrition and dietetics; Temitope Adeyeni, a former graduate student in health science and information and biomedical laboratory science; KayKay San, a former student in biomedical laboratory science; and Rita Heuertz, PhD, professor of biomedical laboratory science.

A DeNardo Education and Research Foundation grant supported the work of the students. The President's Research Fund at SLU provided financial support for Ezekiel.