New Class of Antimicrobials Discovered in Soil Bacteria
Scientists have mined Streptomyces for antibiotics for decades, but the newly identified umbrella toxin escaped notice
Using Automation to Implement Colony Picking Workflows
Colony picking represents a powerful tool within the workflow of mammalian cell line development and the study of microbiology. In the latest years, the use and range of applications of colony screening solutions has continuously increased, in concomitance with the advancement of biotechnology research. Different scientific challenges have been recently faced in this field, from the development of CRISPR-based genome editing technologies to the necessity to produce new efficient therapeutics against SARS-CoV-2. In this regard, 50 drugs were approved by US Food and Drug Administration (FDA) in 2021, 36 of which were new chemical entities and 14 were biologics including peptides, oligonucleotides, and antibody-drug conjugates, thus reflecting the increasing relevance of this class of drugs.
Download eBookIn this context, fast and efficient colony picking and clone screening processes allow to shorten workflow timelines for therapy development, prompting towards quality product improvement and a quicker updating of regulatory processes, which need to align with the guidelines of US FDA. This eBook is aimed to help scientist during the choice of their automated colony picking solution, considering the necessity of high throughput, applications, and major bottlenecks of the process. The focus is on currently available microbial and mammalian clone screening devices and a comparison among different proven technologies is provided.
- A brief history of microbiology and colony picking modern applications
- Optimizing your colony picker's choice
- Experimental workflows
- Mammalian cell line development
- Colony picking automation
- And more!
