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Goal:Optimize a UHPLC/MS method with respect to stationary phase, mobile phase, and detector settings to achieve picogram level quantitation of 14 drugs and metabolites employing a 12 minutes separation.

Positively identify trace amounts of cannabinoids in a complex food matrix quickly, with minimal sample preparation and no chemical derivatization. 

Simvastatin, (together with mevastatin and lovastatin in Figure 1), a hypolipidemic drug belonging to the “statin” family, is commonly used to control elevated cholesterol levels and to prevent cardiovascular diseases.

Vitamin D status has been associated with a variety of disease states including cancer, cardiovascular disease, diabetes, multiple sclerosis, osteoporosis, rheumatoid arthritis, and chronic pain.

LC/MS provides an excellent alternative to conventional LC with UV, PDA or Fluorescence detection or GC/MS to measure polar pesticides in food matrices and in the environment. Many of these pesticides are not very volatile and have to be derivatized

Recent studies suggest parabens may be carcinogenic and can cause estrogenic disrupting activity, thereby disputing the notion of low toxicity for these compounds. We present an LC/MS assay to identify several of the parabens found in hand lotion.

An expired ophthalmic solution of trimethoprim and polymyxin B sulphates was analyzed for degradants using UHPLC/SQ MS.

Here, PerkinElmer reps describe a UHPLC/SQ MS method to separate, identify, and quantify some essential water soluble vitamins without the use of ion pair reagents.

Microvolume assessment of bacterial culture growth was found to facilitate measurement of undiluted cultures. Comparison between microvolume and cuvette-based data requires the use of a conversion factor, which can be simply determined.

Michael Glavanovich receives calls with all kinds of strange requests. Once, a woman phoned to ask him if a piece of meat tossed into her yard for her dog contained poison.