Liquid chromatography coupled with mass spectrometry(LC/MS) is one of the most powerful analytical tools for organic compound analysis.

Goal: Develop a robust LC/MS method for the analysis of illicit drug salt forms.

Goal:Optimize a UHPLC/MS method with respect to stationary phase, mobile phase, and detector settings to achieve picogram level quantitation of 14 drugs and metabolites employing a 12 minutes separation.

Positively identify trace amounts of cannabinoids in a complex food matrix quickly, with minimal sample preparation and no chemical derivatization. 

Simvastatin, (together with mevastatin and lovastatin in Figure 1), a hypolipidemic drug belonging to the “statin” family, is commonly used to control elevated cholesterol levels and to prevent cardiovascular diseases.

Vitamin D status has been associated with a variety of disease states including cancer, cardiovascular disease, diabetes, multiple sclerosis, osteoporosis, rheumatoid arthritis, and chronic pain.

LC/MS provides an excellent alternative to conventional LC with UV, PDA or Fluorescence detection or GC/MS to measure polar pesticides in food matrices and in the environment. Many of these pesticides are not very volatile and have to be derivatized

Recent studies suggest parabens may be carcinogenic and can cause estrogenic disrupting activity, thereby disputing the notion of low toxicity for these compounds. We present an LC/MS assay to identify several of the parabens found in hand lotion.

An expired ophthalmic solution of trimethoprim and polymyxin B sulphates was analyzed for degradants using UHPLC/SQ MS.

Here, PerkinElmer reps describe a UHPLC/SQ MS method to separate, identify, and quantify some essential water soluble vitamins without the use of ion pair reagents.

Our panel of experts will help you understand and apply the basic principles of mass spectrometry theory that are needed for the operation of mass spectrometry systems in the clinical reseach laboratory