CURRENT ISSUE | VOLUME 7 - ISSUE 4 | May 2012
COVER STORY
Appifying the Laboratory
Specialized apps for research are becoming more evident, entrenched, and indispensible
White Papers and Application Notes
Hamilton Company is best known for manufacturing precision fluid measuring products, including syringes for HPLC and GC. For the last 30 years Hamilton Company has manufactured HPLC resins and columns while developing separations for customers.
Reaction screening and purification are essential steps in small molecule pharmaceutical discovery labs. Cleaner samples for subsequent synthesis can reduce reaction by-products and facilitate the critical final purification of material for pharmaceutical profiling and toxicology studies.
Although gold nanoparticle production can be controlled to yield specific size ranges, both the concentration and size of nanoparticles must be checked following production.
Rotary vane Positive Displacement (PD) pumps may be the most commonly used pumps in re-circulating chillers today. Performance and low cost have made them the favored pumps for a variety of applications. T
Field certification of Biological Safety Cabinets (BSC’s) is regulated by the NSF/ANSI 49 Standard, Biosafety Cabinetry: Design, Construction, Performance, and Field Certification, Annex F Field Tests. Section F.1, Field Certification Preconditions and Intervals, discusses when it is necessary to certify BSC’s.
Currently, the most common disinfection process in water and wastewater treatment plants currently uses chlorine gas. A process of ultraviolet (UV) disinfection is being increasingly used in many European countries but in many circumstances, ozonation is preferred.
It has been known for several years that chemicals (e.g., BPA and phlalates) can leach out of the plastic, such as toys and baby bottles. The impact of these chemicals on human health is well known.
It has become crystal-clear to most of us that glass is something we just can’t live without. Scientists use glass beakers for measuring chemicals.
Surveys
Electronic Laboratory Notebooks (ELNs) are software programs that replace paper notebooks in the lab, but they are also more than that, helping to close the electronic gaps among and between data systems. Recently, ELNs have been part of the
Designing a new lab water system or retrofitting an existing system requires a thorough understanding and working knowledge of contaminants, purification technologies, industry standards, user requirements, and water distribution options.
Microplate readers are used to discern either physical, chemical, or biological events in microtiter plates and are common in academia and the biotech, pharmaceutical, and drug discovery industries, as well as in research.
Column technology has been a rich area for HPLC R&D. As reasonably expensive consumables, columns are a significant factor in LC operating costs and performance— in other words, key value drivers.
Products in Action
Starline Track Busway STARLINE Plug-In Raceway, has revolutionized the power distribution industry! Universal Electric Corporation created STARLINE Plug-In Raceway to meet the ever-changing power distribution and datacom needs of research, pharmaceutical, university, hospital and data labs.
Protect your valuable samples with Thermo Scientific 100% pure copper CO2 incubators. The Thermo Scientific 100% pure copper CO2 incubators allow you to culture precious samples, without worry.
For 60 years The Baker Company has been at the forefront of engineering, testing and production of reliable laboratory contamination control equipment. Our cabinets and hoods are crafted with precision for your unique situation.
Laboratory Technology
Systems announced in Orlando could make a big difference in the lab.
As samples become increasingly active and more complex, labs simply cannot afford interferences caused by flow path activity in their GCs. A non-inert flow path can cause peak tailing and signal loss. Users need the most inert flow path possible to achieve the lower detection limits demanded by increasingly tough regulatory obligations.
From a utilitarian standpoint, it was inevitable that technology would redefine the processes of the modern lab. It began with the need to automate as suppliers realized they could help labs significantly improve their products by taking manual work out of the equation.
Managing the pace of technological change that defines next-generation sequencing (NGS) isn’t just an issue for NGS labs. It also challenges the makers of NGS instrumentation. The pressure to stay ahead of the curve is particularly felt in vendor sequencing services labs.
In recent years, research labs have been a notable beneficiary as a variety of highly functional and specialized apps have gained the acceptance and even gratitude of a broad spectrum of laboratory managers, research scientists and bench technologists.
Lab Product
The latest equipment, instruments and system introductions to the laboratory market.
Biological safety cabinets—also known as biosafety cabinets or BSCs— are extremely important in conducting experiments safely in many laboratories that deal with biohazardous material on a regular basis.
How it Works
Strong growth in healthcare spending, especially in emerging economies, is driving increased demand for medical testing, drug discovery, genomics, and proteomics, as well as the instruments used to carry out these processes.
Problem: A mainstay in life science research, western blotting is commonly used to assess relative protein expression differences, such as when investigating cellular signaling pathways. Accurate quantification requires careful attention to procedural details and normalization.
Since the early 1990s, biobanking has been evolving as a key resource, increasing the availability and use of biological material such as DNA, RNA, tissues and cells for biomedical research.
HPLC systems are forced to their pressure limits under fast HPLC and high resolution HPLC conditions. System back pressure issues can arise from efforts to increase efficiency and resolution such as increasing flow rates and column lengths, as well as reducing particle size.
Product Focus
A laboratory information management system (LIMS) consists of software with the ability to perform a wide variety of tasks.
This year marks the 25th anniversary of commercial thermal cyclers for the polymerase chain reaction (PCR). In brief, this technology amplifies segments of DNA.
Modular HPLC systems provide versatility in terms of troubleshooting and repair as well as choice of mobile phase (through the ability to swap out columns rapidly).
The fume hood in your lab might seem ancient, unless you imagine Thomas Edison working in the early 1900s under a fireplace chimney. In the summer, though, Edison’s idea failed to create enough draft as outside temperatures increased.
The right chromatography data system (CDS) can spell the difference between a streamlined data collection process and one that is haphazard. CDSs are software packages that collect, store, and help users interpret data.
Lab Health and Safety Tips
We recommend the establishment of a chemical management system. This system provides for the safe procurement, storage, use and disposal of chemicals.
Ask the Expert
Allis Chien, Ph.D., director of the Vincent Coates Foundation Mass Spectrometry Laboratory at Stanford University’s mass spectrometry shared core resource facility, discusses the advances being made in the instrumentation and applications for mass spectrometry (MS).
Research-Specific Labs
Clean Harbors of Baltimore, Inc., is a transfer storage and disposal facility and part of the largest hazardous waste disposal company in North America.The facility provides recycling, treatment and disposal of a variety of hazardous and nonhazardous wastes and analyzes hundreds of samples each month.
Management Tips
There are certain “guaranteed to make life easier” tips you can use that will make your day flow just a little bit better.
Editor's Buzz
Some expect the mobile apps market to quadruple over the next four years, from $6.8 billion to $25 billion. Others forecast revenues at $29.5 billion by 2013, increasing from $7 billion in 2010.
Business Management
Does your laboratory have “ethical muscle”? Do you feel your employees are flexing this muscle? Ethics and data integrity should be an integral part of your laboratory’s quality program.
Lab Health and Safety
There is a good chance you spend many hours at a computer workstation entering data and researching databases. By setting up your computer workstation optimally and paying attention to a few key elements of positioning and alignment, you can greatly reduce the chance of an ergonomic injury.
Computing and Automation
Automated biological testing can take on many forms, ranging from individual instruments performing a single task to large, room-sized, custom-robotic systems capable of automating very complex tasks. In between these two extremes are simple modular automated systems designed to automate a select series of tasks necessary for a specific assay technology.