Column technology has been a rich area for HPLC R&D. As reasonably expensive consumables, columns are a significant factor in LC operating costs and performance— in other words, key value drivers.

Reaction screening and purification are essential steps in small molecule pharmaceutical discovery labs. Cleaner samples for subsequent synthesis can reduce reaction by-products and facilitate the critical final purification of material for pharmaceutical profiling and toxicology studies.

HPLC systems are forced to their pressure limits under fast HPLC and high resolution HPLC conditions. System back pressure issues can arise from efforts to increase efficiency and resolution such as increasing flow rates and column lengths, as well as reducing particle size.

Modular HPLC systems provide versatility in terms of troubleshooting and repair as well as choice of mobile phase (through the ability to swap out columns rapidly).

Manufacturers of high-performance liquid chromatography (HPLC) systems continue to innovate, while simultaneously providing upgrade paths for older instruments.

As a mature market, filtration moves forward incrementally through improvements in filter media and housings.

HPLC-fluorescence detection is now designated as the official analysis method for many components across various industries