Derek Wachtel, scientist in the DMPK department at Ironwood Pharmaceuticals, and Mingliang Bao, PhD, senior scientist at Labstat International ULC, talk to contributing editor Tanuja Koppal, PhD, regarding various issues they face with sample prep in their laboratories. They both stress that sample prep is very important and a necessary step in any analysis and with newer technologies making it easier and faster to accomplish, there should be no reason to ignore or overlook it.

Thermo Fisher Scientific has developed a high-performance anion-exchange chromatography with pulsed amperometric detection method, based on AOAC Official Method 2011.18, to determine free and bound myo-inositol in infant formula and adult nutritionals.

Get fun facts about sample prep for chromatography, a list of questions to ask when buying chromatography sample prep products, the most recent chromatography sample prep product releases, and an updated chromatography sample prep product manufacturer's list in this section.

Excessive background from endogenous sample matrix components has always been of great concern in bioanalysis, and has become paramount today with the need for decreasing analytical run times.

Routine pipetting tasks across a larger number of samples can often be inefficient, complex, time consuming, and expensive. These hurdles can lead to increased training requirements, preparation time, procedural errors and ultimately hold back the pace of your experiments.

Mechanical sample lysis is rapidly becoming the preferred sample preparation method in life science labs for the isolation of DNA, RNA, proteins, metabolites and other small molecules because the elimination of chemicals, enzymes, and detergents minimizes the introduction of potential inhibitors to downstream processes. The FastPrep-24 5G™ (Fig. 1) is the newest innovation in beat-beaters and produces the fastest lysis of even the most difficult samples.

Thermo Fisher Scientific has developed a rapid and reliable sample preparation procedure and ion chromatography-based method to determine the phytate hydrolysis products in dried distillers grains with 
solubles (DDGS).

AFFINIMIP® SPE Patulin uses a new class of intelligent polymers based on molecularly imprinted polymers specific to Patulin ensuring extremely clean extracts for an easy quantification by all chromatography techniques.

In today's economy laboratories are asking their employees to do more with less, requiring more of both their employees and their equipment.  One way analysts are stepping up is looking for instrumentation that is adaptable for multiple purposes.

Problem: With unrelenting need for accurate sample analysis at lower and lower detection limits, there is pressure on modern laboratories for sample prep instruments that can provide automated, accurate reagent additions to previously prepared liquid samples or for preparing several aliquots of these samples with multiple dilution factors. The catch-all phrase that identifies these devices is “liquid handling systems” and they perform absolutely essential tasks that have a direct and large effect on the ultimate measurement accuracy of both inorganic and organic sample analysis.