CURRENT ISSUE | VOLUME 6 - ISSUE 4 | May 2011
COVER STORY
Laboratory Etiquette
How lapses in etiquette can devastate a lab's morale...
Lab Product
Driven by the pressure to control costs while generating better quality data, automated, unattended, and reliable operation is what lab professionals are looking for from their instruments.
Check this month's featured companies.
The history of chromatography dates back to the mid-19th century
Product Focus
Like the late comedian Rodney Dangerfield, laboratory water purification systems get no respect. Lab workers use them every day, but few realize— beyond opening the spigot—how they operate.
Once the domain of do-it-yourself Ph.D. scientists who spent years studying its intricacies, mass spectrometry (MS) is continuing to go “down market,” says Alessandro Baldi, Ph.D., business manager for MS at PerkinElmer (Waltham, MA).
New materials and ergonomics contribute to ease of operation
Laboratory information management systems (LIMSs) are software packages that connect instruments, other software and sample management to human operators and other data systems, including electronic laboratory notebooks (ELNs).
Lab Health and Safety
Staff reductions can result in severe challenges to proper chemical waste disposal management. In some recent cases, entire large facilities have been closed.
Laboratories frequently accumulate bottles of old chemicals, often toxic or hazardous, that are no longer used. Laboratory managers can use several strategies to properly reuse or dispose of these chemicals.
We all know how diamonds are formed. You take a lump of carbon and subject it to intense pressure and high temperatures, and magically those carbon atoms are pressed into a diamond. The diamonds we are discussing in this article are formed much more easily.
White Papers and Application Notes
Learn more about this system in this application note from RURO.
Incubator contamination is a potential for all incubators. Laboratories have thousands of airborne contaminants that may enter a culture incubator during a door opening and enter the growth environment. High Efficiency Particulate Air (HEPA) filt
This application note describes an automated method for the measurement of pH, Brix and acidity, incorporating a METTLER TOLEDO T90 Titrator, DM45 Density Meter, Rondo60 autosampler and LabX® titration software.
The commercialization of the DSC (Differential Scanning Calorimetry) technique in the 1960s led to a rapid expansion of this method for the thermal characterization of materials.
Consumers and regulatory agencies are expressing more and more interest in the true amount of sodium contained in food products. Sodium has traditionally been indirectly tested using a silver nitrate precipitation reaction.
LECO Corporation continues its history of innovation in high-speed time-of-flight mass spectrometry with the introduction of new High Resolution TOFMS (HRT) instrumentation, available in LC and GC configurations.
It has been known for several years that chemicals (e.g., BPA and phlalates) can leach out of the plastic, such as toys and baby bottles. The impact of these chemicals on human health is well known.
The new heated lid technology, vapo.protect™, featured by the Eppendorf Mastercycler pro, achieves improved evaporation protection even at the corner and edge positions of the thermoblock.
PCR techniques are in widespread use for the amplification of genetic material. The need for reagents and solutions free from nucleases (DNase, RNase) is widely recognized, however, it is vital to also ensure the absence of other waterborne contaminants which could cause problems with test results.
The integrity of samples is paramount in all critical laboratory processes, and important in more routine operations.
Increasing the sensitivity and resolution of LC/MS instruments has been an ongoing focus for instrument manufacturers.
Conventional lab water systems use UV light by flowing water in a chamber around the bulb in a protective quartz sleeve as part of the recirculation loop.
Laboratory Technology
Anyone using a biosafety cabinet should be trained In at least the following.
Some useful resources related to biosafety cabinets.
The latest equipment, instruments and system introductions to the laboratory market.
Panelists from Our February 15th Webinar Outline Some Key Features to Consider When Purchasing a BSC.
This is the first in a three-part series on CO2 incubation. Biological contamination is the dread of every person working with cell culture. Find out how to avoid it
Lab Health and Safety Tips
The use of warning signs to designate particular hazards is not just a good idea. It’s the law.
How it Works
When culturing cells for use in, for example, drug screening assays, maintaining consistently high throughput is essential.
It is essential for medicinal chemists to have access to analytical instrumentation for reaction monitoring and product analysis. However, due to the associated high capital cost and maintenance overheads, it is not possible to install and support instrumentation in every lab across a research site.
The traditional method of testing for microbial contamination has changed very little in the past 100 years. A sample of product is added to a growth medium in a plate or sample container.
Business Management
For most, being organized means “a place for everything and everything in its place,” but the true definition of being organized is being able to find things when you need them, not three weeks later.
Developing profitable new products and processes is the major mission of corporate laboratories. Professors justify their research grants aimed at developing new knowledge by describing how the research can eventually result in new products and processes to create new business, improve health, or protect the environment. Government labs justify their research in the same way.
Leadership and Staffing
Know where the safety equipment is. Don’t eat or drink on the job. Wear the right clothes. And please don’t casually pour chemicals down the drain. Such precautions may sound elementary, but these important and fundamental lab safety practices must be mastered or quality down the line could suffer.
In 2002, the Howard Hughes Medical Institute (HHMI) and the Burroughs Wellcome Fund (BWF) embarked on an educational project to leave no young manager behind.
Many lab managers still remember them from their student days—a handful of hastily stapled printouts sternly titled “Laboratory etiquette—Acceptable standards of conduct.” Those were rules to live by, and the smallest violation landed a budding laboratory scientist in front of the ticked-off chief instructor.
Surveys
One of the primary safety devices in laboratories where chemicals are used is the laboratory fume hood. Continue on to find out the results of our fume hood survey.
A Laboratory Information Management System (LIMS) serves as the interface to a laboratory’s data, instruments, analyses and reports. Read on to find out the results of our LIMS survey.
Laboratory incubators have evolved steadily over the latter part of the twentieth century, and have remained an important piece of laboratory equipment. Find out the results of our lab incubators survey here!
Purchasing Guides
Research-Specific Labs
Wally Thompson is the Microbiology Supervisor at Gambro in Daytona Beach, Florida. Gambro is a global medical technology company, with manufacturing facilities in countries all over the world including Italy, Sweden, Germany, France, Korea, and China, that develops and manufactures products and therapies related to kidney diseases.
Ask the Expert
Daniel Zimmerli, associate scientist and lead of the Separation Science Point group, discusses how his team uses high-performance liquid chromatography (HPLC) and ultra-high performance (or pressure) LC (UHPLC) technologies for analytical and preparative work.