
CURRENT ISSUE | VOLUME 9 - ISSUE 1 | January/February 2014
COVER STORY
Your Lab, Your Business
Maximizing your lab's value to the enterprise
Editor's Buzz
Business Management
Leadership and Staffing

Part one of this article ended with a discussion of politics in your department. We hope you have considered the questions and the implications of the answers.
Products in Action

Combinatorial chemistry can be traced back to the 1960's, but didn't gain popularity until 1990 when pharmaceutical companies started compounding large amounts of potential new drugs into libraries. Now, combinatorial chemistry has moved into other disciplines such as materials science, biotechnology and even semiconductors

With its new 875 Karl Fischer Gas Analyzer, Metrohm combines decades of experience in moisture analysis and sample handling. The KF Gas Analyzer is designed to handle nearly any gas sample - compresses, liquefied or native. It is fully equipped to measure the absolute moisture content of LPG, petrochemical intermediates, natural gas or other compresses or liquefied gases.
Laboratory Technology
Lab Health and Safety
Ask the Expert

Louis Scampavia, PhD, associate professor in the Department of Molecular Therapeutics at the Scripps Research Institute in Florida, talks to contributing editor Tanuja Koppal, PhD, about how automation has been a critical part of their high-throughput screening activities. He goes into the details of what can and should be automated and the due diligence that needs to be performed before these decisions are made—decisions that have a long-standing impact on the workings of a lab.
Product Focus
Research-Specific Labs
Surveys

High-performance liquid chromatography (HPLC) is, for many scientists, an essential chromatographic technique. HPLC systems used for the separation, identification, purification and quantification of various chemical and biochemical solutions are composed of a pump, a sample injector, a separation column, a detection unit, and a data-processor.

While titration is a basic analytical method, titrators are specialized instruments that perform titrations with minimal operator intervention. They can thus minimize errors, improve throughput, and facilitate documentation. There are two major titrator types: potentiometric acid-based designs and Karl Fischer titrators.
Maintenance Matters
How it Works

Problem: Whether due to mergers and acquisitions, lab downsizing, upgrading or outsourcing, many pharmaceutical and biotech companies—large and small—are opting to sell R&D or manufacturing equipment no longer needed in their own labs. This presents a great opportunity for other institutions to obtain late-model, quality equipment at a reduced cost, direct from the working lab. While purchasing second-hand equipment can be a cost effective and socially acceptable way to go, there are potential pitfalls buyers should look out for including: unreliable sellers, equipment contamination, hidden fees, and unverified purchasing channels.

Problem: With unrelenting need for accurate sample analysis at lower and lower detection limits, there is pressure on modern laboratories for sample prep instruments that can provide automated, accurate reagent additions to previously prepared liquid samples or for preparing several aliquots of these samples with multiple dilution factors. The catch-all phrase that identifies these devices is “liquid handling systems” and they perform absolutely essential tasks that have a direct and large effect on the ultimate measurement accuracy of both inorganic and organic sample analysis.
























